De Minaur, who had British girlfriend Katie Boulter courtside cheering his every move, was in an impish mood, chasing down lost causes and extending rallies.
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That did little to help Evans' cause and the Britis player did not have the firepower or the physical longevity to survive.
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He competed for the first two sets, showing grit to level at one set all, but it proved too much.
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Still, he exits the tournament with his pride intact and a place in the record books.
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He also began repairing his dwindling ranking, which plummeted after he chose not to defend 500 points in Washington earlier in the summer in order to feature in the Olympics.
\\r\\n\\r\\n\\r\\n\\r\\nEvans' physical condition deteriorated as the match went on (Adam Hunger/AP)\\r\\n\\r\\n\\r\\n\\r\\n
The first set – and perhaps the match – hinged on an eight-minute game at 3-2.
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After a 27-shot rally, which Evans lost, he regrouped to force break point but could not convert, with the Australian living up to his 'Demon' nickname to hold serve.
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That swung the momentum in his favour and he reeled off the next three games in quick succession, including two breaks, to take the opener.
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Evans was looking increasingly weary, yet found himself serving for the second set after breaking his opponent to love.
The British star, who won the longest match in US Open history in round one, lost 6-3 6-7 6-0 6-0 to the Australian.
Exhausted Dan Evans finally ran out of steam as he exited the US Open in a four-set defeat to Alex de Minaur.
The 34-year-old leaves New York with a piece of history, having won the longest-ever match at the tournament with his five-hour-33-minute first-round victory over Karen Khachanov.
But he paid the price for that physical exertion earlier in the week as he fatigued badly in a 6-3 6-7 (4) 6-0 6-0 loss to the Australian 10th seed.
De Minaur, who had British girlfriend Katie Boulter courtside cheering his every move, was in an impish mood, chasing down lost causes and extending rallies.
That did little to help Evans' cause and the Britis player did not have the firepower or the physical longevity to survive.
He competed for the first two sets, showing grit to level at one set all, but it proved too much.
Still, he exits the tournament with his pride intact and a place in the record books.
He also began repairing his dwindling ranking, which plummeted after he chose not to defend 500 points in Washington earlier in the summer in order to feature in the Olympics.
Evans' physical condition deteriorated as the match went on (Adam Hunger/AP)
The first set – and perhaps the match – hinged on an eight-minute game at 3-2.
After a 27-shot rally, which Evans lost, he regrouped to force break point but could not convert, with the Australian living up to his 'Demon' nickname to hold serve.
That swung the momentum in his favour and he reeled off the next three games in quick succession, including two breaks, to take the opener.
Evans was looking increasingly weary, yet found himself serving for the second set after breaking his opponent to love.